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目的分析血浆碱性磷酸酶(ALP)与糖尿病急性心肌梗死患者生存率的关系。方法测定65例糖尿病合并急性心肌梗死患者的血浆ALP水平,分析心肌梗死后48~60个月患者生存率与患者入院血浆ALP水平的相关性。结果随访48~60个月,患者病死率为30.77%(20/65)。Kaplan-Meier分析显示,与ALP≤74U/L患者比较,ALP>74U/L患者的病死率明显降低。Cox回归分析显示,肌钙蛋白I峰值、年龄、性别、入院血浆肌酐水平、心电图ST段抬高和血红蛋白水平均有统计学意义(P<0.05或P<0.01),血浆ALP水平无统计学意义(P>0.05)。Kaplan-Meier分析显示男性ALP>74U/L患者(30例)的生存率低于ALP≤74U/L患者(10例)(P<0.05),女性患者不明显(P>0.05)。结论 ALP水平可作为预测糖尿病男性患者急性心肌梗死后生存率的指标。
Objective To analyze the relationship between plasma alkaline phosphatase (ALP) and survival rate in patients with acute myocardial infarction (DM). Methods Plasma ALP levels were measured in 65 patients with diabetes mellitus complicated with acute myocardial infarction. The correlation between the survival rate of 48-60 months after myocardial infarction and the level of plasma ALP in hospitalized patients was analyzed. Results The follow-up of 48 to 60 months, the patient mortality was 30.77% (20/65). Kaplan-Meier analysis showed that patients with ALP> 74U / L had a significantly lower case fatality rate than patients with ALP <74U / L. Cox regression analysis showed that peak values of troponin I, age, sex, plasma creatinine level, ST segment elevation and hemoglobin level in ECG were statistically significant (P <0.05 or P <0.01), while plasma ALP level was not statistically significant (P> 0.05). Kaplan-Meier analysis showed that the survival rate of male patients with ALP> 74U / L (30 cases) was lower than that of ALP≤74U / L patients (10 cases) (P <0.05). Conclusions ALP level can be used as a predictor of survival after acute myocardial infarction in male patients with diabetes mellitus.