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反相氰基柱高效液相色谱分析阿曲库铵苯磺酸盐（卡肌宁）样品，采用乙腈－水－磷酸－硫酸四元流动相基线分离并同时测定阿曲库铵苯磺酸盐及相关化合物，甲醇－硫酸流动相系统分离测定阿曲库铵苯磺酸盐的顺－顺、顺－反和反－反三种立体异构体，考察了流动相各组分浓度变化对化合物色谱保留值和分离度的影响。方法重现性好，线性范围较宽，检测限为１０ｎｇ。
Determination of Atacuronium Benzene Sulfonate (Kagang Ning) by High Performance Liquid Chromatography with a Reversed-phase Cyanide Column and Baseline Simultaneous Determination of Atracurium and Benzene Sulfonate by Acetonitrile-Water-Phosphoric Acid-Sulfuric Acid Mobile Phase And cis-cis, cis-trans and trans-trans with the relevant compounds and mobile phase of methanol-sulfuric acid were studied. The effect of the concentration of each component of mobile phase on the activity of compound Chromatographic retention and resolution. The method has good reproducibility and wide linear range with a detection limit of 10ng.