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目的了解广东省人群白喉抗体水平,为评估白喉输入与传播风险提供依据。方法根据地域抽取河源、湛江、珠海3个地市共27所医疗机构作为监测点,采集902名0~49岁门诊病人的血清标本,采用酶联免疫吸附试验(ELISA)间接法检测白喉Ig G抗体,分析白喉抗体的分布特征。结果在902名调查对象中,白喉Ig G抗体滴度达到部分保护水平(≥0.01 IU/ml)占100%,达到安全保护水平(≥0.1IU/ml)占58.8%,达到长期保护水平(≥0.1IU/ml)占16.9%;抗体几何平均滴度(GMT)为0.203 IU/ml(95%CI:0.184 IU/ml~0.224 IU/ml)。年龄与白喉Ig G抗体滴度呈负相关(r=-0.43,P<0.001);其中0~9岁和10~49岁人群达到安全保护保护水平的比例分别为77.0%和39.0%。结论广东省人群白喉抗体水平较高,发生白喉暴发疫情的可能性不大。大年龄组人群白喉抗体水平低,建议对<50岁成人适时加强接种1剂含白喉类毒素成分疫苗。
Objective To understand the level of diphtheria antibodies in Guangdong population and to provide a basis for assessing the risk of diphtheria input and transmission. Methods Totally 902 medical institutions in three cities of Heyuan, Zhanjiang and Zhuhai were selected as the monitoring points to collect 902 serum samples of outpatients from 0 to 49 years old. The detection of diphtheria Ig G by enzyme-linked immunosorbent assay (ELISA) Antibodies were analyzed for the distribution of diphtheria antibodies. Results In 902 subjects, diphtheria Ig G antibody titers reached 100% (≥0.01 IU / ml), reached the level of protection (≥0.1 IU / ml), accounting for 58.8%, reaching the level of long-term protection (≥ 0.1 IU / ml) accounted for 16.9%. The geometric mean antibody titer (GMT) was 0.203 IU / ml (95% CI: 0.184 IU / ml to 0.224 IU / ml). There was a negative correlation between age and diphtheria Ig G antibody titers (r = -0.43, P <0.001). The proportion of protective and protective levels of 0 to 9 years old and 10 to 49 years old were 77.0% and 39.0% respectively. Conclusion The level of diphtheria antibodies in Guangdong population is high, and the possibility of diphtheria outbreak is unlikely. Diphtheria antibody levels in older age groups are low, and it is recommended that a dose of diphtheria toxoid-containing vaccine be given to humans <50 years old in a timely manner.