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目的:考察奥硝唑注射液接瓶头孢唑肟钠注射液后溶液的稳定性,确保临床安全联用。方法:模拟临床两药联用、序贯输入的给药过程,配制不同质量比的配伍液,间隔一定时间对配伍液的外观性状、pH及含量进行考察;并进行紫外-可见光谱扫描,观察峰形、峰位的变化。结果:头孢唑肟钠与奥硝唑质量比为0.004～0.100的各配伍液在10～55 min内由淡微黄色变为淡微粉色;各配伍液在2 h内pH及奥硝唑含量基本保持不变;紫外图谱显示2 h内峰形和峰位没有变化,但放置12 h后在波长502 nm处出现一小峰,且奥硝唑的吸收值下降。结论:为确保两药安全有效的联用,建议在头孢唑肟钠输注结束时用适量0.9%氯化钠注射液或注射用水将输液管中的药物冲净后,再换接奥硝唑注射液。
OBJECTIVE: To investigate the stability of the solution after injection of ornidazole injection ceftizoxime sodium injection to ensure the safety of clinical use. Methods: The combination of clinical two drugs, sequential input of the drug delivery process, the preparation of different mass ratio of compatibility of liquid, at intervals of the compatibility of the appearance of liquid properties, pH and content were investigated; and UV - Visible spectrum scanning Peak shape, peak position changes. Results: The compatibility of ceftizoxime and ornidazole from 0.004 to 0.100 changed from light yellow to light pink within 10 ~ 55 minutes. The pH and ornidazole content of each compatibility solution within 2 h UV spectroscopy showed no change in peak shape and peak position within 2 h, but a small peak appeared at 502 nm after 12 h, and the absorption of ornidazole decreased. Conclusion: In order to ensure the safe and effective combination of the two drugs, it is advisable to rinse the infusion tube with appropriate amount of 0.9% sodium chloride injection or water for injection after ceftizoxime sodium infusion and exchange with ornidazole Injection.