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收集114例临床确诊肝胆胰疾病患者血清,应用贝克曼全自动免疫分析仪(Array Protein Systen m)联合定量检测11种血清蛋白质,发现胆管结石及胆囊疾病患者血清IgG、IgA,IgM、AAT和AMG升高,TRF和CER降低,而C3、C4、AAG和CRP正常;胰腺疾病IgG、IgA和AAT升高,TRF和CER降低,IgM、C3、C4、AAG、AMG及CRP正常;肝癌患者IgG、IgA、IgM、AMG、AAT和CRP升高,TRF降低,C3、C4、AAG和CER正常;肝硬化患者IgG、IgA、IgM、AMG和AAT升高,C3、C4、TRF、AAG和CER降低,CRP正常.肝胆结石与非肝胆结石患者比较,血清IgG、IgA、IgM、CER和AMG降低,C3和C4升高,这对临床鉴别诊断有一定意义.肝胆结石患者手术后CRP、IgA和AAG明显升高,是术后观察的有用指标.11种血清蛋白质分别与Bil-T、ALP和ALT测定结果作相关性分析,发现C3与ALP、TRF与ALT呈正相关,其余蛋白质与Bil-T、ALP和ALT则相关不显著(P>0.05).
114 serum samples from patients with clinically diagnosed hepatobiliary and pancreatic diseases were collected and quantified by using the Array Protein Systen m to detect 11 serum proteins. Serum IgG, IgA, IgM, AAT and AMG were found in patients with cholelithiasis and gallbladder disease. Elevated, TRF and CER decreased, while C3, C4, AAG, and CRP were normal; IgG, IgA, and AAT increased in pancreatic diseases; TRF and CER decreased; IgM, C3, C4, AAG, AMG, and CRP were normal; IgG, IgA, IgM, AMG, AAT, and CRP increased, TRF decreased, C3, C4, AAG, and CER were normal; IgG, IgA, IgM, AMG, and AAT increased in patients with cirrhosis, and C3, C4, TRF, AAG, and CER decreased. CRP is normal. Compared with patients with non-hepatic gallstones, serum gallstones and IgG, IgA, IgM, CER, and AMG are decreased, and C3 and C4 are increased. This has certain significance for clinical differential diagnosis. Postoperative CRP, IgA in patients with hepatolithiasis A significant increase in AAG and AAG is a useful indicator for postoperative observation. Eleven serum proteins were correlated with Bil-T, ALP, and ALT results. Correlations were found between C3 and ALP, TRF, and ALT. The remaining proteins were associated with Bil- There was no significant correlation between T, ALP and ALT (P>0.05).