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目的:探讨注射用阿莫西林钠克拉维酸钾溶液的稳定性。方法:本次医学研究通过高效液相色谱法测定了不同阿莫西林钠克拉维酸钾溶液的药物含量和稳定性。结果:在氯化钠中,注射用阿莫西林钠克拉维酸钾溶液具有较好的稳定性,克拉维酸钾和阿莫西林钠含量会在3h内降低到10%以下;在葡萄糖注射液中,注射用阿莫西林钠克拉维酸钾溶液具有较差的稳定性,葡萄糖含量与药物有效含量之间为正相关关系。结论:本次医学研究结果证实,注射用阿莫西林钠克拉维酸钾溶液在不同溶液中稳定性具有一定的差异,因此需要在3h内完成给药过程。
Objective: To investigate the stability of amoxicillin sodium clavulanate potassium solution for injection. Methods: The medical study determined the drug content and stability of different amoxicillin sodium clavulanate potassium solution by high performance liquid chromatography. Results: Amoxicillin sodium clavulanate potassium solution for injection had good stability in sodium chloride. The contents of potassium clavulanate and amoxicillin sodium decreased to less than 10% in 3h. In glucose injection , The amoxicillin sodium clavulanate potassium solution for injection has poorer stability, and there is a positive correlation between the glucose content and the effective content of the drug. Conclusion: The results of this medical study confirm that the amoxicillin and sodium clavulanate solution for injection has some differences in stability in different solutions. Therefore, it is necessary to complete the administration within 3 hours.