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银胶菊内酯是一种从艾菊属植物中提取的倍半萜类化合物,作为一种西方传统药物,具有良好的免疫调节功效,应用十分广泛,在体内外实验中也显示了抗菌、抗炎等药理作用。在不同的细胞株中,其作用机制也不同。文中从银胶菊内酯抑制核转录因子-κB(NF-κB)信号通路、阻断STAT3信号通路发挥其生物活性以及抗氧化、抗肿瘤等方面,综述了近年来国外报道的有关银胶菊内酯的多种分子作用机制的研究进展,为银胶菊内酯进一步深入研究和开发利用提供参考。
Ginkgolide is a sesquiterpene compound extracted from plants of the genus Asteraceae. It has a good immunomodulatory effect as a Western traditional medicine. It has a wide range of applications. It also shows antibacterial activity in both in vitro and in vivo experiments. Anti-inflammatory and other pharmacological effects. In different cell lines, the mechanism of action is also different. In this paper, we reviewed the effects of ginkgolactone on nuclear factor-κB (NF-κB) signaling pathway, blockade of STAT3 signaling pathway and its biological activities, as well as its anti-oxidation and anti-tumor effects. The research progress of various molecular mechanisms of action of lactones provides a reference for the further research, development and utilization of echinacolide.