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目的比较分析中、德两国不同研究中心所在区域2型糖尿病发病特点的差异,为两国糖尿病发病率及病程进展的进一步深入对比研究提供基础数据。方法采用简单随机抽样方法,对中、德两个研究中心所在医院的住院2型糖尿病患者进行调查。针对患者病程、人体测量学数据、实验室检测数据及糖尿病并发症患病率等方面进行对比研究。结果两组患者的糖尿病病程差异具有统计学意义,德国组平均病程长于中国组(P<0.01)。德国组患者体质量、腰围、体质量指数、收缩压均明显高于中国组(P<0,01)。中国组患者甘油三脂、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇均高于德国组,尤其甘油三脂水平差异有统计学意义(P<0.01)。德国组肾小球滤过率低于中国组(P<0.05)。两组间在糖化血红蛋白、血清肌酐、尿蛋白、尿蛋白/肌酐比值的比较上差异无统计学意义(P>0.05)。德国组患者糖尿病肾病、心血管病变、糖尿病周围神经病变、糖尿病周围血管病变的发病率明显高于中国组,两组间差异有统计学意义(P<0.01)。结论中、德双方差异主要体现在糖尿病患者的人口特征和典型糖尿病终末器官损伤的表现上。
Objective To compare and analyze the differences in the incidence of type 2 diabetes among different research centers in China and Germany, and provide basic data for further in-depth comparative study on the incidence and progression of diabetes in both countries. Methods A simple random sampling method was used to investigate the inpatients with type 2 diabetes in two hospitals where Chinese and German research institutes are located. According to the patient’s course of disease, anthropometric data, laboratory test data and the prevalence of diabetic complications and other aspects of comparative study. Results The difference in duration of diabetes between the two groups was statistically significant. The average duration of diabetes in Germany was longer than that in China (P <0.01). Body mass, waist circumference, body mass index and systolic blood pressure were significantly higher in the German group than in the Chinese group (P <0,01). In Chinese patients, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol were higher than those in German group, especially in triglyceride (P <0.01). Glomerular filtration rate was lower in Germany than in China (P <0.05). There was no significant difference between the two groups in the ratio of HbA1c, creatinine, urinary protein and urine protein / creatinine (P> 0.05). The incidence of diabetic nephropathy, cardiovascular disease, diabetic peripheral neuropathy and diabetic peripheral vascular disease in German group was significantly higher than that in Chinese group, with significant difference between the two groups (P <0.01). Conclusion The differences between China and Germany are mainly reflected in the demographic characteristics of diabetic patients and the performance of typical terminal organ damage in diabetes.