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DNA错配修复(MMR)基因hMLH1、hMSH2、hMSH6、hPMS2等种系突变与遗传性非息肉病性结直肠癌(HNPCC)易感性相关。hEXO1能与hMSH2产生很强的相互作用,参与错配修复过程和或DNA重组[1～7]。本研究采用DNA测序筛查16个中国人HNPCC和低风险HNPCC家系hEXO1基因所有13个编码外显子和1个
Mutations in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2, hMSH6 and hPMS2 are associated with susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). hEXO1 has a strong interaction with hMSH2 and is involved in mismatch repair processes and / or DNA recombination [1-7]. In this study, DNA sequencing was used to screen all 13 coding exons and 1 hEXO1 gene in 16 Chinese HNPCC and low-risk HNPCC families