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目的:观察贞芪扶正颗粒配合伽玛刀治疗晚期非小细胞肺癌的临床疗效及副反应。方法:对81例失去手术机会拟行伽玛刀治疗的中晚期肺癌住院患者随机分为治疗组41例和对照组40例。2组均经伽玛刀治疗后常规对症治疗,治疗组加口服贞芪扶正颗粒。2组病例均采用体部伽玛刀立体定向放射治疗。结果:治疗组和对照组的近期疗效分别为60.97%和57.5%,放射性肺炎的发生率为4.87%和17.5%。结论:对于晚期非小细胞肺癌,采用贞芪扶正颗粒配合伽玛刀治疗,可以明显减轻伽玛刀的不良反应,提高患者生存质量。
Objective: To observe the clinical efficacy and side effects of Zhenqi Fuzheng granule combined with gamma knife in the treatment of advanced non-small cell lung cancer. Methods: A total of 81 inpatients with advanced lung cancer scheduled for gamma knife surgery who lost their chance of surgery were randomly divided into treatment group (n = 41) and control group (n = 40). 2 groups were treated by Gamma Knife conventional symptomatic treatment, the treatment group plus oral Zhengqifuzheng particles. Two groups of patients were using body gamma knife stereotactic radiotherapy. Results: The short-term effects of the treatment group and the control group were 60.97% and 57.5% respectively, and the incidences of radiation pneumonitis were 4.87% and 17.5%. Conclusion: For advanced non-small cell lung cancer, the use of Zhenqi Fuzheng granule with gamma knife treatment can significantly reduce the adverse reactions of gamma knife and improve the quality of life of patients.