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系统性红斑狼疮(SLE)是一种常见的自身免疫性疾病.研究探讨自身抗体及常规实验室检查对SLE的诊断及临床意义.间接免疫荧光法检测ANA抗体和抗ds-DNA抗体,斑点法检测抗ENA抗体,透射比浊法检测免疫蛋白,生化检查方法按试剂说明.143例SLE患者中,女性121例,ANA、ds-DNA、SS-A、n-RNP/Sm、Sm、SS-B阳性率分别为97.6%、57.8%、52.4%、48.9%、21.5%、11.7%,未检出Scl-70和Jo-1抗体.SLE患者血清抗ds-DNA抗体与抗Sm阳性有显著差别(P<0.05).在143例SLE患者中,IgG(35.66%)、IgA(36.36%)、RF(29.37%)升高,C3(85.3%)、C4(68.5%)降低.常规检查中,血红蛋白量(71.33%)、血钾(34.27%)、ALB(89.51%)降低,尿潜血和尿蛋白阳性率分别为28.67%和41.96%,ESR(83.22%)加快,肝功酶谱(30%~40%)升高.自身抗体检测结合常规检查有利于SLE的诊断和治疗.
Systemic lupus erythematosus (SLE) is a common autoimmune disease.Studies on the diagnosis and clinical significance of autoantibodies and routine laboratory tests on SLE.And indirect immunofluorescence assay for detecting ANA antibody and anti-dsDNA antibody, Detection of anti-ENA antibodies, transmission nephelometry detection of immune proteins, biochemical methods according to reagent instructions.143 cases of SLE patients, 121 females, ANA, ds-DNA, SS-A, n-RNP / Sm, B positive rate were 97.6%, 57.8%, 52.4%, 48.9%, 21.5% and 11.7%, respectively.No detection of Scl-70 and Jo-1 antibodies was found in serum of patients with SLE (P <0.05) .Among 143 SLE patients, IgG (35.66%), IgA (36.36%) and RF (29.37%) were elevated, C3 (85.3%) and C4 The positive rate of urinary occult blood and urinary protein were 28.67% and 41.96%, ESR (83.22%) and hepatic zymogram (30%) were significantly higher than those of normal controls (71.33%, 34.27%, 89.51% ~ 40%) increased.Abodies combined with routine examination is conducive to the diagnosis and treatment of SLE.