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炎症性肠病与肠道黏膜免疫系统对肠腔内细菌和食物抗原等异常免疫应答有密切关系,在炎症肠黏膜组织内有大量激活的单个核淋巴细胞浸润,表达高水平的促炎症细胞因子和辅助刺激信号分子等.NK细胞是先天性和获得性免疫应答的重要淋巴细胞,主要通过分泌细胞毒杀伤蛋白质对靶细胞进行直接杀伤,并分泌促炎症介质.在炎症性肠病患者炎症肠黏膜组织内有大量NK细胞浸润,表达高水平激活分子,并分泌促炎症细胞因子,参与肠黏膜炎症损伤.
Inflammatory bowel disease and the intestinal mucosal immune system on intestinal bacteria and food antigens and other abnormal immune response are closely related to a large number of inflammatory intestinal mucosa in a single activation of lymphocytes infiltration, the expression of high levels of proinflammatory cytokines And auxiliary stimulus signal molecules, etc. NK cells are innate and adaptive immune response of important lymphocytes, mainly through the secretion of cytotoxic proteins directly kill target cells, and secretion of proinflammatory mediators.In the inflammatory bowel disease in patients with inflammatory bowel Mucosal tissue with a large number of NK cell infiltration, expression of high levels of activator molecules, and secretion of proinflammatory cytokines involved in inflammation of the intestinal mucosa.