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目的:分析右美托咪定复合依托咪酯麻醉对于胃癌根治术患者术后血流动力学及其抗感染的影响。方法:选取2015年10月—2016年10月期间收治的胃癌根治术患者100例,按入院时间为序将其分为对照组和观察组患者,每组50例;对照组患者给予依托咪酯诱导麻醉,观察组患者在对照组基础上加用右美托咪定诱导麻醉,比较两组患者术后血流动力学及其抗感染的影响。结果:对照组患者在用药时和拔管时的心率低于观察组(P<0.05);两组患者拔管时的心率和不同时间的舒张压、收缩压经组间比较其差异无统计学意义(P>0.05),麻醉效果之间经组间比较其差异无统计学意义(P>0.05);观察组患者术后感染率低于对照组(P<0.05)。结论:采用右美托咪定与依托咪酯诱导麻醉对胃癌根治术患者的血流动力学较稳定,降低了术后感染的发生率。
Objective: To analyze the effect of dexmedetomidine combined etomidate anesthesia on postoperative hemodynamics and anti-infection in patients with gastric cancer undergoing radical operation. Methods: A total of 100 gastric cancer patients who underwent radical gastrectomy between October 2015 and October 2016 were enrolled in this study. They were divided into control group and observation group according to the sequence of hospitalization, 50 cases in each group. Patients in the control group were given etomidate Induction of anesthesia, the observation group patients on the basis of the control group plus dexmedetomidine induction of anesthesia, postoperative hemodynamics and anti-infection effects were compared between the two groups. Results: The heart rate of patients in the control group at the time of extubation and administration was lower than that of the observation group (P <0.05). There was no significant difference in heart rate and diastolic blood pressure and systolic blood pressure at extubation between the two groups (P> 0.05). There was no significant difference between the two groups in the anesthetic effect (P> 0.05). The infection rate in the observation group was lower than that in the control group (P <0.05). CONCLUSIONS: The use of dexmedetomidine and etomidate-induced anesthesia provides a more stable hemodynamic response to radical gastrectomy and reduces the incidence of postoperative infection.