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目的探讨不良孕产史与染色体异常的关系。方法采用外周血淋巴细胞染色体分析。结果 701例有不良生育史患者,染色体查出异常核型35例,其中染色体数目异常1例,占异常核型的2.86%(1/35);染色体结构异常24例,占异常核型的68.57%(24/35),包括平衡易位8例,倒位15例,未知起源的附加物1例;染色体多态性变异10例,占异常核型的28.57%(10/35)。结论染色体异常是导致不良孕产史的重要原因之一,它不但与染色体结构异常有关,而且与染色体多态性也有关联。
Objective To investigate the relationship between poor pregnancy history and chromosomal abnormalities. Methods Chromosome analysis of peripheral blood lymphocytes. Results Among the 701 patients with unfavorable maternal history, there were 35 cases with abnormal karyotype detected in chromosomal abnormalities, of which 1 was chromosomal abnormality, accounting for 2.86% (1/35) of abnormal karyotype; 24 cases were chromosomal abnormalities, accounting for 68.57 % (24/35), including 8 cases of balanced translocation, 15 cases of inversion and 1 case of unknown origin; 10 cases of chromosomal variation, accounting for 28.57% (10/35) of abnormal karyotype. Conclusion Chromosomal abnormalities are one of the most important causes of adverse maternal history. It is not only related to chromosomal abnormalities but also to chromosomal polymorphisms.