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目的观察蒙脱石(思密达)与奥美拉唑、阿莫西林、克拉霉素联合治疗消化性溃疡(PU)的疗效。方法147例幽门螺杆菌(Hp)阳性PU,随机分为治疗组75例,对照组72例。2组第1～2周均服奥美拉唑、阿莫西林、克拉霉素,第3～4周均服奥美拉唑。治疗组第1～4周加服蒙脱石。结果治疗组与对照组溃疡愈合率91%,72%,2组比较差异有统计学意义(P<0.05)。Hp根除率93%、75%,差异有统计学意义(P<0.05)。结论思密达与奥美拉唑、阿莫西林、克拉霉素联用,溃疡愈合率及Hp根除率高,不良反应少,值得临床上推广。
Objective To observe the curative effect of montmorillonite (Smecta) combined with omeprazole, amoxicillin and clarithromycin in the treatment of peptic ulcer (PU). Methods 147 cases of Helicobacter pylori (Hp) -positive PU were randomly divided into treatment group (75 cases) and control group (72 cases). Omeprazole, amoxicillin and clarithromycin were administered in the first two weeks in both groups, and omeprazole was administered in the third to fourth weeks. Treatment group 1 to 4 weeks plus montmorillonite. Results The healing rate of ulcer in the treatment group and the control group was 91% and 72%, respectively. There was significant difference between the two groups (P <0.05). Hp eradication rate of 93%, 75%, the difference was statistically significant (P <0.05). Conclusion Smecta combined with omeprazole, amoxicillin, clarithromycin, ulcer healing rate and Hp eradication rate, fewer adverse reactions, worthy of clinical promotion.