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日本研究人员已发现了他们认为与人类胃癌有关的一个癌基因。1985年9月底,上述的研究结果由研究组的领导人Kenji Shimizu在日本仙台的一次会议上宣布,并在9月的ProcUS Nat Acad Sct(82:5641.)上发表。 Shimizu研究小组对此项发现特别兴奋,因为在日本的常见肿瘤中,胃癌是首屈一指的。Shimizu在九洲大学的生物系工作、该系是日本癌基因研究的一个中心。Shimizu的研究始于1984年,此研究项目是一项与癌瘤有关的十年研究计划[New Scientist 107(1464):33,1985]。研究小组实验中用的DNA是东京国立癌瘤中心从病人切除的胃癌组织直接进行克隆的。Shimizu转染了NIB 3T3细胞,这是小鼠细胞,曾作为检出“转化”癌基因的一种方法
Japanese researchers have discovered an oncogene they believe is related to human gastric cancer. At the end of September 1985, the above findings were announced by the research team leader Kenji Shimizu at a meeting in Sendai, Japan and published in September at ProcUS Nat Acad Sct (82:5641.). The Shimizu research team was particularly excited about this discovery because gastric cancer is second to none in Japan’s most common cancers. Shimizu works in the Department of Biology at Jiuzhou University, which is a center of Japanese oncogene research. Shimizu’s research began in 1984. This research project is a 10-year research project related to cancer (New Scientist 107(1464):33, 1985). The DNA used by the team’s experiment was cloned directly by the National Cancer Center of Tokyo from the patient’s resection of gastric cancer tissue. Shimizu was transfected with NIB 3T3 cells, a mouse cell that was used as a method to detect “transformation” of oncogenes.