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目的探讨乌体林斯治疗支气管哮喘远期效果及对机体免疫、变态反应指标的影响,以期为乌体林斯治疗支气管哮喘近、远期疗效提供可靠依据。方法选取支气管哮喘患儿104例,随机单盲取法分为观察组与对照组各52例,对照组给予常规治疗,观察组在对照组基础上给予乌体林斯治疗,观察两组患者治疗前后免疫指标(T淋巴细胞及亚群:CD3+、CD4+、CD8+、CD4+/CD8+;免疫蛋白:Ig A、Ig G、Ig M、Ig E)、变态反应相关指标嗜酸性粒细胞(EOS)、嗜酸细胞阳离子蛋白(ECP)及白细胞介素-4(IL-4)变化。治疗后随访1年,观察两组患儿复发情况。结果两组治疗前各项免疫指标及变态反应相关指标比较,差异无统计学意义,观察组治疗后Ig G、Ig M、CD3+、CD8+、CD4+/CD8+均高于同组治疗前及对照组同期(P<0.05),Ig E低于同组治疗前及对照组同期(P<0.05),各项变态反应相关指标均低于同组治疗前及对照组治疗后(P<0.05),观察组治疗8周总有效51例,总有效率98.1%,高于对照组的40例(76.9%),差异有统计学意义(P<0.05),随访1年观察组2例患儿复发,对照组15例复发,两组复发率比较,差异有统计学意义(P<0.05)。结论支气管哮喘患儿给予乌体林斯,可提高患儿免疫功能,改善变态反应,提高治疗效果,降低远期复发率,值得临床推广。
OBJECTIVE To investigate the long-term effects of radiotherm on bronchial asthma and its effects on the immune and allergic reaction of bronchial asthma, in order to provide a reliable basis for the treatment of bronchial asthma in the short and long term. Methods A total of 104 children with bronchial asthma were randomly divided into two groups: observation group (52 cases) and control group (52 cases). The control group was given routine treatment. The observation group was treated with outillate on the basis of the control group. Before and after treatment Immunological indicators (T lymphocytes and subgroups: CD3 +, CD4 +, CD8 +, CD4 + / CD8 +; immune proteins: Ig A, Ig G, Ig M, Ig E), allergic related indicators eosinophils (EOS) Changes of cell cationic protein (ECP) and interleukin-4 (IL-4). Followed up for 1 year after treatment, observed the recurrence of children in both groups. Results Before treatment, the immunological indexes and allergy-related indexes were not significantly different between the two groups. Ig G, Ig M, CD3 +, CD8 + and CD4 + / CD8 + in the observation group were significantly higher than those before treatment and in the control group (P <0.05). Ig E was lower than that of the same group before treatment and in the control group (P <0.05), and the indexes of all the allergic reactions were lower than those of the control group before treatment and the control group (P <0.05) The total effective rate was 8 weeks (51 cases), the total effective rate was 98.1%, higher than that of the control group (76.9%), the difference was statistically significant (P <0.05) 15 cases relapsed, the recurrence rate of the two groups, the difference was statistically significant (P <0.05). Conclusion Asthmatic children with bronchial asthma, can improve children’s immune function, improve allergic reactions, improve the therapeutic effect and reduce the long-term recurrence rate, worthy of clinical promotion.