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目的 对血清TRACP5b作为骨吸收生化标志物进行临床研究。方法 利用BoneTRAP试剂盒 ,对 473例正常及骨质疏松患者血清做TRACP5b检测及分析。结果 男性和女性 ,随年龄的增加 ,特别是男性更年期及女性绝经期后 ,血清TRACP5b水平均不断升高 ,表明骨吸收增强 ;当患有骨质疏松后 ,血清中TRACP5b的水平高于同龄人 ,且男性及女性骨质疏松患者血清TRACP5b水平均高于正常人 ,统计学提示有显著性差异。结论 血清TRACP5b是一个较好的骨吸收监测指标
Objective To investigate the clinical significance of serum TRACP5b as a biomarker of bone resorption. Methods The BoneTRAP kit was used to detect and analyze TRACP5b in 473 normal and osteoporotic patients. Results Male and female, with increasing age, especially male menopause and post-menopausal women, serum TRACP5b levels were continuously increased, indicating increased bone resorption; when suffering from osteoporosis, serum TRACP5b levels were higher than their peers , And serum levels of TRACP5b in both men and women with osteoporosis were higher than those in normal people. There was a statistically significant difference between the two groups. Conclusion Serum TRACP5b is a good indicator of bone resorption