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目的：比较粒细胞－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）与粒细胞集落刺激因子（Ｇ－ＣＳＦ）治疗因化学治疗（化疗）致骨髓抑制的疗效。方法：３９例恶性肿瘤病人随机分ＧＭ－ＣＳＦ组１８例（男性１２例，女性６例，中位年龄４２ａ）与Ｇ－ＣＳＦ组２１例（男性１３例，女性８例，中位年龄５３ａ）。因化疗后引起骨髓抑制，分别应用ＧＭ－ＣＳＦ１５０μｇ／ｄ与Ｇ－ＣＳＦ１００μｇ／ｄ，ｓｃ，ｑｄ×（２～６）ｄ。结果：２组外周血白细胞总数及中性粒细胞计数与用药前比较均上升（Ｐ＜０．０１），２组间比较无显著差异（Ｐ＞０．０５）。不良反应均少而轻。结论：ＧＭ－ＣＳＦ与Ｇ－ＣＳＦ治疗化疗所致的骨髓抑制，效果相似。
Objective: To compare the efficacy of GM-CSF and G-CSF in the treatment of bone marrow suppression induced by chemotherapy (chemotherapy). Methods: Thirty-nine patients with malignant tumor were randomly divided into two groups: 18 patients (12 males, 6 females, median age 42a) and 21 patients (13 males and 8 females, median age 53a) . Due to chemotherapy-induced bone marrow suppression, GM-CSF150μg / d and G-CSF100μg / d, sc, qd × (2-6) d were applied. Results: The total number of leukocytes and neutrophil count in two groups increased compared with those before treatment (P <0.01). There was no significant difference between the two groups (P> 0.05). Adverse reactions are less and less. Conclusion: The effect of GM-CSF and G-CSF on bone marrow suppression induced by chemotherapy is similar.