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目的评价重度子痫前期患者左室形态及功能变化,并探讨二尖瓣舒张早期E波峰值流速与舒张早期二尖瓣环心肌运动峰值速度之比(E/Ea)、收缩期二尖瓣环心肌运动峰值速度(Sa)评价重度子痫前期患者早期左室功能异常的临床意义及其与N-端脑利钠肽前体(NT-pro BNP)的相关性。方法 36例重度子痫前期患者和51例血压正常孕妇(对照组)。运用超声心动图测量左室形态参数,包括舒张末期左室前后径(LVDd)、舒张末期室间隔厚度(IVSd)、舒张末期左室后壁厚度(LVPWd);运用超声心动图测量左室功能参数,包括射血分数(LVEF)、二尖瓣瓣口舒张早期E波峰值流速与舒张晚期A波峰值流速比值(E/A)、收缩期二尖瓣环左室侧壁处心肌运动峰值速度(Sa),舒张早期二尖瓣环左室侧壁处心肌运动峰值速度(Ea),计算E与Ea比值(E/Ea)。同时检测血浆N-端脑利钠肽前体浓度。结果与对照组比较,重度子痫前期组左室形态各参数均明显增加,差异有统计学意义(P<0.01);重度子痫前期组Sa明显降低,E/Ea明显增大,差异有统计学意义(P<0.01),E/A减小,差异有统计学意义(P<0.05)。NT-pro BNP与E/Ea呈正相关(r值为0.58,P<0.05);NT-pro BNP与Sa呈负相关(r值为-0.69,P<0.05)。结论重度子痫前期患者可以导致左室形态和功能发生变化,应用超声心动图测量E/Ea、Sa与NT-pro BNP相关性良好,可以作为评价左室功能的早期指标,
Objective To evaluate the changes of left ventricular morphology and function in patients with severe preeclampsia and to investigate the relationship between mitral annular mitral annular velocity (E / Ea) and peak systolic mitral annular velocity Clinical Significance of Peak Cardiac Muscle Velocity (Sa) in Evaluating Early Left Ventricular Function in Patients with Severe Eclampsia and Its Correlation with N-terminal Brain Natriuretic Peptide Precursors (NT-pro BNP). Methods Thirty-six patients with severe preeclampsia and 51 normotensive pregnant women (control group) were enrolled. Left ventricular morphological parameters were measured by echocardiography, including left ventricular anteroposterior diameter (LVDd), end diastolic septal thickness (IVSd) and left ventricular posterior wall thickness (LVPWd); echocardiography was used to measure left ventricular function parameters Including ejection fraction (LVEF), early diastolic mitral E-wave peak velocity and late diastolic A-wave peak velocity (E / A), systolic mitral annular velocity at left ventricular wall (Ea), and E / Ea ratio (E / Ea) was calculated. Plasma N-terminal pro-brain natriuretic peptide concentrations were also measured simultaneously. Results Compared with the control group, all the parameters of left ventricular morphology in severe preeclampsia group were significantly increased (P <0.01), the level of Sa in severe preeclampsia group was significantly lower, E / Ea was significantly increased, the difference was statistically significant Significance (P <0.01), E / A decreased, the difference was statistically significant (P <0.05). NT-pro BNP was positively correlated with E / Ea (r = 0.58, P <0.05); NT-pro BNP was negatively correlated with Sa (r = -0.69, P <0.05). Conclusion Severe preeclampsia patients can lead to changes in left ventricular morphology and function, E / Ea measured by echocardiography, Sa and NT-pro BNP good correlation can be used as an early indicator of left ventricular function,