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目的探讨慢性牙周炎与子痫前期患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和C-反应蛋白(C-reactive protein,CRP)水平变化及相关关系。方法选取经确诊的26～36周的伴牙周炎的子痫前期妊娠妇女[(PE+CP)组]21例,单纯子痫前期妊娠妇女(PE组)21例,单纯慢性牙周炎妊娠妇女(CP组)21例,无以上2种疾病及其他系统性疾病的正常健康妊娠妇女(H组)21例。记录菌斑指数(PI)、牙周探诊深度(PD)、附着水平丧失(AL)和探诊出血(BOP),检测血清中TNF-α、IL-6及CRP的含量。结果各组间牙周病指数(PD、AL、BOP)比较有统计学差异。(PE+CP)组、PE组、CP组与H组相比,TNF-α、IL-6、CRP水平明显升高,差异有统计学意义(P<0.05),(PE+CP)组的TNF-α、IL-6、CRP水平均高于PE组及CP组,差异有统计学意义(P<0.05)。结论 TNF-α、IL-6、CRP可能与子痫前期和牙周炎病理机制相关,牙周炎和子痫前期之间存在一定的关联。
Objective To investigate the changes of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) levels in patients with chronic periodontitis and preeclampsia relationship. Methods Twenty-one cases of preeclamptic pregnant women [(PE + CP) group) with 21 ~ 36 weeks of convalescent periodontitis, 21 cases of pure preeclamptic pregnant women (PE group), 21 cases of chronic periodontitis pregnancy Twenty-one women (group CP), 21 healthy pregnant women (group H) without any of the above two diseases and other systemic diseases. The plaque index (PI), periodontal exploration depth (PD), attachment level loss (AL) and probe bleeding (BOP) were recorded. The levels of TNF-α, IL-6 and CRP in serum were detected. Results The periodontal disease index (PD, AL, BOP) in each group was statistically different. The levels of TNF-α, IL-6 and CRP in PE + CP group, PE group and CP group were significantly higher than those in H group (P <0.05) The levels of TNF-α, IL-6 and CRP were significantly higher than those in PE and CP groups (P <0.05). Conclusion TNF-α, IL-6 and CRP may be related to the pathogenesis of preeclampsia and periodontitis. There is a correlation between periodontitis and preeclampsia.