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水通道蛋白(AQPs)是一组小分子跨膜蛋白家族,对水分子有高度通透性,表达谱广泛,且参与细胞的水代谢。子宫内膜癌是妇科发病率最高的恶性肿瘤之一,最常见的病理类型是子宫内膜腺癌,其发病与长期雌激素的刺激相关,但子宫内膜腺癌发生发展的分子机制尚未完全阐明。AQPs可通过促进细胞生长、血管新生、细胞迁移几个方面影响肿瘤的生长和发展,AQPs在子宫内膜癌中表达上调,参与子宫内膜癌血管新生,并与子宫内膜癌分期分级等临床病理特征存在相关性。
Aquaporins (AQPs) are a group of small-molecule transmembrane proteins that are highly permeable to water molecules and have a broad spectrum of expression and are involved in the cellular metabolism of water. Endometrial cancer is the highest incidence of gynecological malignant tumors, the most common pathological type is endometrial adenocarcinoma, the incidence of estrogen-related and long-term stimulation, but the molecular mechanism of endometrial adenocarcinoma has not yet been fully developed Clarify. AQPs can affect tumor growth and development by promoting cell growth, angiogenesis and cell migration. AQPs are upregulated in endometrial cancer, involved in angiogenesis of endometrial cancer, and are clinically associated with staging of endometrial cancer Pathological features are related.