作者为观察抗疟药对杀伤细胞活性的影响,进行了自发性细胞介导的细胞毒性试验。从健康人末梢血液中先后用密度梯度离心、吞噬铁粉和E与EAC玫瑰花结等方法分离出杀伤细胞。取此细胞与抗疟药或药物的溶剂等容量混和,37℃孵育30分钟,洗涤后即为试验的效应细胞。试验的抗疟药为氯喹、奎 To investigate the effect of antimalarial drugs on killer cell activity, a spontaneous cell-mediated cytotoxicity assay was performed. The killer cells were isolated from the peripheral blood of healthy individuals by density gradient centrifugation, phagocytosis of iron powder and E and EAC rosettes. This cell was mixed with the antimalarial drug or the solvent of the drug, and incubated at 37°C for 30 minutes. After washing, the cells were tested as effector cells. The antimalarial drug tested was chloroquine and quinol