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目的探讨ER、CerbB-2、Caspase-3在乳腺浸润性导管癌组织中的表达情况及与临床病理参数的关系。方法应用免疫组化SP法检测132例乳腺浸润性导管癌中ER、CerbB-2、Caspase-3的表达情况。结果 ER、CerbB-2、Caspase-3在癌组织中的表达分别为56.1%(74/132)、36.4%(48/132)、59.8%(79/132)。其中ER表达阳性及阴性癌组织中淋巴结转移率分别为14.9%(11/74)、37.9%(22/58);ER表达阳性及阴性癌组织中组织学分级1、2级比例分别为83.8%(62/74)、56.9%(33/58);CerbB-2表达阳性及阴性癌组织中淋巴结转移率分别为37.5%(18/48)、17.9%(15/84);CerbB-2表达阳性及阴性癌组织中组织学分级1、2级比例分别为77.1%(37/48)、69.0%(58/84);Caspase-3表达阳性及阴性癌组织中淋巴结转移率分别为15.2%(12/79)、39.6%(21/53);Caspase-3表达阳性及阴性癌组织中组织学分级1、2级比例分别为83.5%(66/79)、54.7%(29/53)。除去不同CerbB-2表达癌组织中组织学分级1、2外,以上参数均有显著差异。结论乳腺癌的发生发展受到多种因子的调控,细胞凋亡受到抑制是重要因素之一。
Objective To investigate the expression of ER, CerbB-2 and Caspase-3 in breast invasive ductal carcinoma and its relationship with clinicopathological parameters. Methods The expressions of ER, CerbB-2 and Caspase-3 in 132 cases of invasive ductal carcinoma of the breast were detected by immunohistochemical SP method. Results The expressions of CerbB-2, CerpB-2 and Caspase-3 were 56.1% (74/132), 36.4% (48/132) and 59.8% (79/132) respectively. The positive rates of lymph node metastasis in ER positive and negative cancerous tissues were 14.9% (11/74) and 37.9% (22/58), respectively. The positive rates of histological grading and negative angiogenesis were 83.8% (62/74) and 56.9% (33/58) respectively. The rates of lymph node metastasis in CerbB-2 positive and negative cancerous tissues were 37.5% (18/48) and 17.9% (15/84), respectively. CerbB- (77.1% (37/48) and 69.0% (58/84) respectively). The rates of lymph node metastasis in the positive cases of Caspase-3 and negative cancers were 15.2% (12 /79),39.6%(21/53). The histological grading 1,2 and 3 levels in Caspase-3 positive and negative cancerous tissues were 83.5% (66/79) and 54.7% (29/53), respectively. The above parameters were significantly different except for histological grade 1 and 2 in different CerbB-2-expressing cancer tissues. Conclusion The occurrence and development of breast cancer are regulated by many factors and the inhibition of apoptosis is one of the important factors.