论文部分内容阅读
观察10例健康人与12例高血压病人可乐定(clonidino)诱导生长激素释放的区别以及在β受体阻断剂普洛茶尔(propranolol)作用1周后10例高血压病人可乐定/生长激素(C/GH)试验的变化。研究证明中枢神经α_2受体激动剂可乐定(150ug)静注后30、60 min,正常人血清生长激素分别增加7.8和6.4倍,高血压病人分别增加2.3和1.7倍(P<0.01),提示高血压病人有中枢神经α_2受体功能紊乱。10例病人接受普洛萘尔治疗1周后,在已经出现明显心率减慢,可乐定降压作用被拮抗的同时,病人可乐定/生长激素试验反应低下的状态未能纠正,提示高血压病人视丘下部的α_2受体有选择性损害。
To observe the difference of clonidino-induced growth hormone release between 10 healthy subjects and 12 hypertensive patients, and clonidine / growth in 10 hypertensive patients one week after propranolol, a beta-receptor antagonist, Hormone (C / GH) test changes. Studies have shown that 30 and 60 minutes after intravenous administration of clonidine (150ug), a central nervous system agonist, increased serum levels of growth hormone by 7.8 times and 6.4 times in normal subjects and increased by 2.3 and 1.7 times (P <0.01) respectively, suggesting that Hypertensive patients have central α 2 receptor dysfunction. One week after the 10 patients were treated with pallotoxine, there was an apparent slowing of the heart rate and the antihypertensive effect of clonidine was antagonized. At the same time, the patient’s low response to clonidine / growth hormone test failed to correct, suggesting that patients with hypertension Ocular inferior α 2 receptor selective damage.