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急性淋巴细胞性白血病是儿童最常见的恶性肿瘤之一。对其免疫状态的研究已有不少报道,但有关中枢神经系统白血病(CNSL)儿童脑脊液(CSF)中肿瘤坏死因子α(TNFa)、可溶性白细胞介素2受体(sIL_2R)的研究尚不多见。我们对23例急性淋巴细胞白血病患儿(其中12例为CNSL)CSF中TNFa、sIL_2R进行了测定,以了解其在CNSL儿童的临床意义。
Acute lymphoblastic leukemia is one of the most common malignancies in children. However, there are not many studies on TNFα and sIL_2R in cerebrospinal fluid (CSF) of children with central nervous system leukemia (CNSL) see. We measured the levels of TNFa and sIL_2R in CSF of 23 patients with acute lymphoblastic leukemia (12 of them were CNSL) in order to understand its clinical significance in children with CNSL.