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目的：探讨系统性红斑狼疮（ＳＬＥ）患者临床首发症状与国外患者的异同性。方法：将１１３例ＳＬＥ患者的临床首发症状与ＭＣＧＥ－ＨＡＮＶＥＹ报导的 １０５例［５］（以下简称Ｍ２８０）相比较。结果：面部蝶形红斑的发生率较Ｍ２８０偏高（Ｐ＞０．０５），雷诺氏现象的发生率比对照偏高（Ｐ＞０．０５），发热的发生率则偏高（Ｐ＜０．０１），肾脏病变及贫血的发生率相似（Ｐ＞００５），关节受累则偏低（Ｐ＜０．０１），另胸膜炎，心包炎，癫痫的发生率偏低（Ｐ＞０．０５）。关节炎和发热症状具统计学意义，其他症状无统计学意义。结论：ＳＬＥ症状具多样性，因此应重视早期诊断和治疗。
Objective: To explore the similarities and differences between the first clinical symptom in patients with systemic lupus erythematosus (SLE) and foreign patients. Methods: The clinical first symptom of 113 SLE patients was compared with 105 cases reported by MCGE-HANVEY [5] (hereinafter referred to as M280). Results: The incidence of facial butterfly erythema was higher than that of M280 (P> 0.05). The incidence of Raynaud’s disease was higher than that of control (P> 0.05) and the incidence of fever was higher (P <0. (P <0.01). The incidence of renal disease and anemia was similar (P> 0.05), the joint involvement was lower (P <0.01) and the incidence of pleurisy, pericarditis and epilepsy was lower (P> 0.05) . Arthritis and fever symptoms with statistical significance, other symptoms were not statistically significant. Conclusion: The symptoms of SLE are diverse, so early diagnosis and treatment should be emphasized.