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七十年代以前,小细胞肺癌(SCLC)的主要治疗手段为手术、放疗,或手术+放疗。即使是可切除病例,5年生存率也仅达1—3％,因为确诊时往往已有扩散。七十年代以后,联合化疗对SCLC有较好的疗效,且可延长生存期,八十年代联合化疗已成为SCLC的标准治疗方法。一般采用化疗+放疗。近几年来,化疗结合手术治疗小细胞肺癌是可行的,可使早期SCLC5年生存率达40％左右,因而SCLC综合治疗有可能提高远期疗效。
Before the 1970s, the main treatment for small cell lung cancer (SCLC) was surgery, radiotherapy, or surgery + radiotherapy. Even with resectable cases, the 5-year survival rate is only 1-3%, because the diagnosis often has spread. After the 1970s, combined chemotherapy has a good effect on SCLC and can prolong survival. In the 1980s, combined chemotherapy has become the standard treatment for SCLC. Generally use chemotherapy + radiotherapy. In recent years, chemotherapy combined with surgical treatment of small cell lung cancer is feasible, and the early 5-year survival rate of SCLC is about 40%. Therefore, comprehensive treatment with SCLC may improve long-term efficacy.