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目的探索新生儿体内降钙素原变化的临床意义。方法 120例新生儿为研究对象,根据新生儿感染程度分为重症感染组、局部感染组和非感染组,每组40例,对比分子三组新生儿的降钙素原、C反应蛋白、白细胞介素-6检测水平。结果重症感染组患儿的降钙素原为(34.05±12.36)ng/ml、白细胞介素-6为(178.56±24.36)ng/L、C反应蛋白为(26.31±5.36)mg/L,局部感染组患儿的降钙素原为(12.30±1.05)ng/ml、白细胞介素-6为(75.39±10.02)ng/L、C反应蛋白为(12.36±2.04)mg/L,非感染组新生儿的降钙素原为(0.32±0.41)ng/ml、白细胞介素-6为(8.36±2.04)ng/L、C反应蛋白为(7.62±2.05)mg/L。重症感染组均高于局部感染组和非感染组,局部感染组均高于非感染组,差异均具有统计学意义(P<0.05)。降钙素原在重症感染患儿中敏感性为93.75%,特异性为87.50%,漏诊率为6.25%,误诊率为12.50%。降钙素原在局部感染患儿中的敏感度为96.67%,特异度为90.00%,漏诊率为3.33%,误诊率为10.00%。结论降钙素原能够反映新生儿感染程度,持续性升高可提示预后差。
Objective To explore the clinical significance of procalcitonin in neonates. Methods A total of 120 newborns were divided into severe infection group, local infection group and non-infected group according to the degree of neonatal infection. Forty infants in each group were enrolled in the study. One hundred and three newborn infants were randomly divided into three groups: procalcitonin, C-reactive protein, leucocyte Interleukin -6 detection level. Results Serum procalcitonin (34.05 ± 12.36) ng / ml, interleukin-6 was (178.56 ± 24.36) ng / L and C-reactive protein was (26.31 ± 5.36) mg / The level of procalcitonin in the infected group was (12.30 ± 1.05) ng / ml, the interleukin-6 was (75.39 ± 10.02) ng / L and the C-reactive protein was (12.36 ± 2.04) mg / Neonates had procalcitonin (0.32 ± 0.41) ng / ml, interleukin-6 (8.36 ± 2.04) ng / L, and C-reactive protein (7.62 ± 2.05) mg / L. Severe infection group were higher than the local infection group and non-infected group, the local infection group were higher than non-infected group, the difference was statistically significant (P <0.05). The procalcitonin in children with severe infection was 93.75% with specificity of 87.50%, missed diagnosis rate of 6.25% and misdiagnosis rate of 12.50%. The procalcitonin sensitivity in children with local infection was 96.67%, specificity was 90.00%, the rate of misdiagnosis was 3.33% and the rate of misdiagnosis was 10.00%. Conclusion Procalcitonin can reflect the degree of neonatal infection, persistent increase may indicate poor prognosis.