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目的:探讨灵芝水煎剂对束缚应激小鼠血清胰岛素样生长因子-I(IGF-I)含量的影响.方法:以不同剂量的灵芝水煎剂给应激前的小鼠灌胃10d,应激20h后用放射免疫分析法(RIA)测定其血清IGF-I的含量.结果:束缚应激前以8g/(kg.d)灵芝水煎剂灌胃的小鼠,束缚应激期间血清IGF-I含量比单纯应激小鼠增加了32%(P<0.01).结论:口服灵芝水煎剂有对抗应激所致的血清IGF-I含量下降的作用,能预防或减轻应激给机体带来的危害.
Objective: To investigate the effect of Ganoderma lucidum decoction on serum insulin-like growth factor-I (IGF-I) in restraint-stress mice. Methods: The mice before stress were given intragastric administration for 10 days with different doses of Ganoderma decoction. The serum IGF-I levels were determined by radioimmunoassay (RIA) after 20 hours of stress. Results: mice fed with Ganoderma decoction 8 g/(kg.d) before restraint stress, serum during restraint stress The IGF-I content was increased by 32% (P<0.01) compared with the stress mice alone. Conclusion: Oral ganoderma lucidum decoction has the effect of reducing the serum IGF-I level caused by stress and can prevent or reduce the stress. The harm caused by the body.