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目的：探讨检测系统性红斑狼疮(SLE)病人血浆可溶性血栓调节蛋白(sTM)的临床意义。方法：应用酶联免疫吸附法(ELISA)测定46例SLE病人和20名正常人血浆sTM水平，分析sTM与SLE活动期疾病活动度的关系。结果：SLE活动期组sTM水平高于非活动期组和对照组(P ＜0．01)。sTM与多个SLE疾病活动度评分相关，与低补体C3血症、抗双链脱氧核糖核酸（dsDNA）抗体滴度水平相关(P ＜0．05)。高水平sTM与狼疮肾炎、浆膜炎相关(P ＜0．01)。结论：血浆sTM水平与SLE活动期和疾病活动度有较好的相关性，可作为判断SLE疾病活动性的指标。
Objective: To investigate the clinical significance of detecting plasma soluble thrombomodulin (sTM) in patients with systemic lupus erythematosus (SLE). Methods: Plasma sTM levels were measured in 46 patients with SLE and 20 normal controls by enzyme-linked immunosorbent assay (ELISA), and the relationship between sTM and disease activity in active SLE patients was analyzed. Results: The level of sTM in active SLE group was higher than inactive group and control group (P <0.01). sTM was associated with multiple SLE disease activity scores and was associated with low complement C3 hyperlipidemia and anti-dsDNA antibody titers (P <0.05). High levels of sTM were associated with lupus nephritis and serositis (P <0.01). Conclusion: There is a good correlation between plasma sTM level and SLE activity and disease activity, which can be used as an index to judge the activity of SLE disease.