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肿瘤干细胞具有自我更新和可塑性的潜能,能够维持肿瘤生长和异质性的能力.肿瘤干细胞是肿瘤产生、转移、耐药和复发的根源,肿瘤干细胞学说逐渐被肿瘤研究者所接受,因此,对肿瘤干细胞的深入理解有重大的科学和临床意义.肿瘤干细胞的微环境是肿瘤微环境的组成部分,包括细胞-细胞接触、分泌型因子等.肿瘤非干细胞和肿瘤干细胞本身都可以作为肿瘤干细胞的微环境.肿瘤干细胞的微环境可以维持肿瘤干细胞的可塑性,保护肿瘤干细胞免受免疫系统攻击,也可以促进其转移.肿瘤干细胞对其微环境的塑造、肿瘤干细胞的微环境对肿瘤干细胞自我更新的影响,以及针对肿瘤干细胞微环境的靶向干预等问题,已成为肿瘤干细胞研究的前沿问题.本文就肿瘤干细胞的发现、自我更新维持机制、肿瘤干细胞的微环境,及其肿瘤干细胞及微环境的干预策略等研究进展进行了综述.
Cancer stem cells have the potential of self-renewal and plasticity, and can maintain tumor growth and heterogeneity.Cancer stem cells are the root of tumor generation, metastasis, drug resistance and recurrence, tumor stem cell theory is gradually accepted by tumor researchers, therefore, In-depth understanding of cancer stem cells has great scientific and clinical significance.Cancer stem cell microenvironment is part of the tumor microenvironment, including cell-cell contact, secretory factor, etc. Tumor non-stem cells and cancer stem cells themselves can be used as tumor stem cells Microenvironment of cancer stem cells can maintain the plasticity of cancer stem cells, protect cancer stem cells from attack by immune system, and promote the metastasis of tumor stem cells. The shaping of microenvironment by tumor stem cells, the self-renewal of cancer stem cells by microenvironment of tumor stem cells Influence, and targeted intervention of tumor stem cell microenvironment have become the frontier issue of cancer stem cell research.In this paper, the discovery of tumor stem cells, the mechanism of self-renewal and maintenance, the microenvironment of tumor stem cells, and their cancer stem cells and microenvironment Intervention strategies and other research progress Summary of the line.