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子宫颈癌的化疗以往收效甚微。有人报道仅用博莱霉素治疗16例子宫颈癌患者,其中1例完全消退,2例部分缓解。氨甲喋呤对头颈部鳞状细胞癌有效,但对子宫颈癌无效。著者报告手术及/或放射治疗后复发或转移的子宫颈癌患者20例,因皆不愿再做根治术,采用博莱霉素和氨甲喋呤的联合化疗。前者每周一次皮下注射10毫克/平方米,后者每4天口服10毫克/平方米。两种药物同时开始。白细胞低于3,000时,停用氨甲喋呤,恢复到3,500或以上时,再使用。血小板少于75,000时,停氨甲喋呤。粘膜出现溃疡时,亦停
Chemotherapy for cervical cancer has had little success in the past. It has been reported that only 16 patients with cervical cancer were treated with bleomycin alone, in which 1 patient completely resolved and 2 patients had partial remission. Methotrexate is effective for head and neck squamous cell carcinoma but not for cervical cancer. The authors reported that 20 patients with recurrent or metastatic cervical cancer after surgery and/or radiation therapy were reluctant to undergo radical resection. A combination of bleomycin and methotrexate chemotherapy was used. The former is subcutaneously injected with 10 mg/m2 once a week, and the latter is taken orally at 10 mg/m2 every 4 days. Both drugs started at the same time. When the number of white blood cells is below 3,000, methotrexate is stopped, and when it is restored to 3,500 or more, it is used again. When the platelets were less than 75,000, the methotrexate was stopped. When mucosal ulcers occur, they stop