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以大剂量水杨酸为主的治疗风湿热,已有一百年的历史。其主要副作用是水杨酸中毒、对胃的刺激、出血倾向和过敏反应。但大剂量水杨酸治疗风湿热诱发中毒性肝炎,却罕有报道。本文之目的在于强调:对大剂量水杨酸治疗的患者,监测其血清水杨酸的浓度和肝脏功能,是非常重要的。一、病例和方法本文病例均来自沙特阿拉伯Dhahran健康中心1979年7月15日至1984年1月15日期间住院的急性风湿热患儿。其诊断均依照修改的Jone’s标准,即必须至少有一项主要指标,两项次要指标和存有近期链球菌感染的证据。
A large dose of salicylic acid-based treatment of rheumatic fever, has a hundred years of history. The main side effects are salicylate poisoning, irritation to the stomach, bleeding tendency and allergic reactions. However, high-dose salicylic acid treatment of rheumatic fever induced toxic hepatitis, but rarely reported. The purpose of this article is to emphasize that it is important to monitor the serum salicylic acid concentration and liver function in patients treated with high-dose salicylic acid. First, the case and methods of this case were from Dhahran Health Center in Saudi Arabia from July 15, 1979 to January 15, 1984 hospitalized patients with acute rheumatic fever. The diagnosis is based on the revised Jone’s criteria, ie, there must be at least one major indicator, two minor indicators and evidence of recent streptococcal infection.