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目的回顾分析常规IVF受精完全失败在临床中的发生情况及受精失败后应用补救性卵母细胞内单精子注射(ICSI)的临床结局。方法总结1999年5月~2009年5月,在我中心行常规IVF患者中,受精完全失败的发生情况。回顾性分析了2004年1月!2009年5月,因受精完全失败行补救性ICSI后的临床结局。结果 1999年至2009年5月,我中心共行常规IVF 8359个周期,其中,受精完全失败232个周期,发生率为2.78%。2004年1月至2009年5月,共184个周期受精完全失败,资料完整,对其中115个周期共838个MII期卵子行补救性ICSI,其受精率、卵裂率与优质胚胎率分别为71.0%、93.78%和51.79%;临床妊娠率为11%,获得活产儿5个。结论补救性ICSI能获得较高的受精率和卵裂率,降低周期取消率,但并没有明显增加活产儿出生数,改善妊娠结局。
Objective To retrospectively analyze the clinical occurrence of conventional IVF insemination in general and the clinical outcome of intracoronary injection of intracytoplasmic sperm injection (ICSI) after fertilization failure. Methods From May 1999 to May 2009, the incidence of complete failure of fertilization in IVF patients in our center was summarized. The clinical outcomes after salvage ICSI were retrospectively analyzed from January 2004 to May 2009 due to complete failure of fertilization. Results From 1999 to May 2009, our center had 8359 cycles of routine IVF, of which 232 cycles of complete failure of fertilization occurred, with a rate of 2.78%. From January 2004 to May 2009, a total of 184 cycles of fertilization failed completely, and the data were complete. Among them, a total of 838 MII eggs with 115 cycles were given rescue ICSI. The fertilization rate, cleavage rate and quality embryo rate were 71.0%, 93.78% and 51.79% respectively. The clinical pregnancy rate was 11%, and 5 live births were obtained. Conclusion Remedial ICSI can obtain higher fertilization rate and cleavage rate, reduce the cycle cancellation rate, but did not significantly increase the number of live births and improve pregnancy outcomes.