目的 :肢体缺血再灌注不仅可以引起局部组织的损伤 ,同时亦可引起远隔部位的多器官损伤 ,其中肺脏是最易受损的器官之一 ,若发生急性肺损伤 ,可导致呼吸功能不全。研究证明此种肺损伤与氧化应激有关。血红素氧化酶 (ＨＯ)是催化血红素生成胆绿素和ＣＯ的限速酶 ,诱导型血红素氧 OBJECTIVE: Ischemia and reperfusion of limbs can not only cause local tissue damage, but also cause multiple organ damage in distant parts. Among them, the lungs are one of the most vulnerable organs. If acute lung injury occurs, it may lead to respiratory insufficiency . Studies have shown that such lung injury and oxidative stress. Heme oxygenase (HO) is a rate-limiting enzyme that catalyzes the formation of heme and CO by heme, and the inducible heme oxygen