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目的观察奥沙利铂(L-OHP)联合5-氟尿嘧啶(5-Fu)和亚叶酸钙(CF)治疗晚期胃癌的近期疗效及不良反应。方法第1天,L-OHP 130mg/m2,静滴2 h;第1~5天,CF100 mg/m2,静滴2 h;第1~5天,5-Fu 300 mg/m2,于CF后静滴,维持6 h;21 d或28 d为1个周期,2个周期评价疗效。结果CR4例,PR13例,SD14例,PD5例,有效率47.2%。主要不良反应为骨髓抑制、消化道反应及感觉性神经毒性。结论L-OHP联合5-Fu和CF治疗晚期胃癌疗效较好,不良反应轻,能耐受,值得进一步在临床推广使用。
Objective To observe the short-term effects and side effects of oxaliplatin (L-OHP) combined with 5-fluorouracil and leucovorin (CF) in the treatment of advanced gastric cancer. On the first day of the method, L-OHP 130 mg / m2, intravenous infusion 2 h; on the first 5 days CF100 mg / m2, intravenous infusion 2 h; on the first 5 days, 5-Fu 300 mg / Intravenous infusion, maintaining 6 h; 21 d or 28 d for a cycle, 2 cycles evaluation of efficacy. Results CR4 cases, PR13 cases, SD14 cases, PD5 cases, the effective rate was 47.2%. The main adverse reactions were myelosuppression, gastrointestinal reactions and sensory neurotoxicity. Conclusion The combination of L-OHP and 5-Fu and CF in the treatment of advanced gastric cancer has better curative effect, less adverse reactions and more tolerability. It is worth further promotion and use in clinic.