目的 :超极化激活电流 (Ih)通道对神经元动作电位的爆发起重要作用 ,本工作检验其在炎症痛中的作用。方法 :用完全弗氏佐剂诱发关节炎模型 ,用全细胞电流钳、电压钳技术研究炎症后大鼠背根神经节 (DRG)细胞Ih 通道的特性。结果 :炎症大鼠DRG细胞Ih 通道的翻转电位、最大电流密度没有改变 ,说明Ih 通道的结构及表达的数量没有变化。但Ih 通道的半激活电位向去极化移动 ,说明Ih 通道的活性增加 ;电流钳记录表明 ,炎症大鼠DRG神经元中 ,具有Ih 的中、小型细胞动作电位增宽 ,小型细胞动作电位频率增加。结论 :上述变化可以加速细纤维传入神经递质的释放 ,从而放大了伤害性感觉信号 ,这可能是引起炎症痛敏的重要原因 PURPOSE: The hyperpolarization-activated current (Ih) channel plays an important role in the firing of neuronal action potentials. This work examines its role in inflammatory pain. Methods: The arthritis model was induced by complete Freund ’s adjuvant. The characteristics of Ih channel in rat DRG cells were studied by whole cell current clamp and voltage clamp technique. Results: There was no change in the reversal potentials and maximum current density of Ih channels in DRG cells of inflamed rats, indicating that the number and structure of Ih channels did not change. However, the half-activation potential of Ih channel shifted to depolarization, indicating that the activity of Ih channel increased. Current clamp recording showed that the action potentials of small and medium-sized cells with Ih in broiler DRG neurons were broadened, increase. Conclusion: The above changes can accelerate the release of fine fibers into the neurotransmitter, thus amplifying the nociception sensation, which may be an important cause of hyperalgesia