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目的 探讨鉴别良恶性腹水的新方法。方法 比较两组患者 12 6例血清C -12肿瘤标志物的检测情况。结果恶性腹水组血清CEA、AFP、CA19-9及CA2 42水平较良性腹水组升高 (P <0 0 1) ,其诊断恶性腹水的敏感性分别为 73 6%,76 4%,87 5 %,3 6 1%,特异性分别为 88 9%,81 5 %,79 6%及 98 1%。C -12结果中 3项以上阳性对恶性腹水的敏感性为 62 5 %,特异性达 96 3 %。结论 肿瘤标志物检测有助于良恶性腹水的鉴别诊断 ,C -12可同时检测 12种肿瘤标志物 ,可提高诊断恶性腹水的敏感性和特异性
Objective To explore a new method to identify benign and malignant ascites. Methods Twenty-six serum C-12 tumor markers in two groups were compared. Results The serum levels of CEA, AFP, CA19-9 and CA2 42 in malignant ascites group were significantly higher than those in benign ascites group (P <0.01). The sensitivity of malignant ascites was 73.6%, 76.4%, 87.5% , 36.1% and 88.9%, 81.5%, 79.6% and 98.1% respectively. The sensitivity of 3 or more positives in C-12 results to malignant ascites was 62.5% and the specificity was 96.3%. Conclusion The detection of tumor markers is helpful for the differential diagnosis of benign and malignant ascites. C-12 can simultaneously detect 12 kinds of tumor markers, which can improve the sensitivity and specificity of the diagnosis of malignant ascites