利福平是人体药物代谢的强效诱导剂,可引起肝细胞色素P-450含量增多。它的酶诱导作用使某些药物的清除率增加。因此,利福平与其他药物相互作用具有潜在临床意义。口服抗凝剂 1975年O’Reilly治疗8例病人,使用华法林7.5～10mg/d、利福平600mg/d,共21d。最后10d发现低凝血酶原血症效应,血浆华法林水平明显下降,尿和粪中华法林代谢物含量增加。 Rifampicin is a potent inducer of human drug metabolism, can cause increased liver cytochrome P-450 content. Its enzyme-induced effect increases the clearance rate of certain drugs. Therefore, the interaction between rifampin and other drugs has potential clinical significance. Oral anticoagulant O’Reilly treated 8 patients in 1975 with warfarin 7.5-10 mg / day and rifampicin 600 mg / day for 21 days. In the last 10 days, the effect of low prothrombinmia was found, the plasma warfarin level was significantly decreased, and the metabolites of warfarin in urine and feces were increased.