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目的探讨氯喹对烟雾吸入伤大鼠肺微血管通透性的影响。方法健康Ｗｉｓｔａｒ大鼠随机分成正常对照组，吸入伤１，３，５，１２，２４ｈ组及氯喹治疗６ｈ和１２ｈ组。肺含水量用干湿重法测定，肺微血管通透性用１３１Ｉ－白蛋白渗出量表示，肺出血量用９９Ｔｃ标记的红细胞出量表示。结果烟雾吸入伤后肺水含量、１３１Ｉ－白蛋白渗出量明显增加，至伤后６ｈ达峰值（Ｐ＜０．０１），而肺内９９Ｔｃ红细胞出量以伤后１ｈ最明显，伤后２４ｈ仍明显高于正常对照组（Ｐ＜０．０１），氯喹治疗伤后６ｈ组，上述指标明显低于吸入伤６ｈ组（Ｐ＜０．０１）。结论氯喹可以明显降低烟雾吸入伤大鼠肺微血管通透性。
Objective To investigate the effects of chloroquine on the permeability of pulmonary microvessels in rats exposed to smoke inhalation. Methods Healthy Wistar rats were randomly divided into normal control group, inhalation injury 1,3,5,12,24h group and chloroquine group 6h and 12h. Pulmonary water content was measured by dry-wet method, pulmonary microvascular permeability with 131I-albumin exudation that the amount of pulmonary hemorrhage 99Tc labeled erythrocytes output. Results After inhalation of smoke, the lung water content and the amount of 131I-albumin exudation increased significantly (P <0.01), but the peak value of 99Tc red blood cells in the lung was the most obvious at 1 hour after injury, (P <0.01), and chloroquine was significantly lower than the 6h group (P <0.01). Conclusion Chloroquine can significantly reduce pulmonary microvascular permeability in rats exposed to smoke inhalation.