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多年来对联合放化疗治疗小细胞肺癌的时间和顺序一直存有争议。 自1988年2月到1989年9月,美国东部肿瘤协作组和M.D Anderson癌症中心对以上做了比较。全部病人均经病理或细胞学证实,病变局限在一侧胸腔内,无胸水和心包积液,K氏分数在70分以上。放化疗序贯组的化疗方案为:环磷酰胺750mg/m~2,第一天;长春新碱2mg,第8天;顺铂20mg/m~2;第1～3天;足叶己甙100mg/m~2,第1～3天; 3周为一疗程,共3个疗程。化疗后完全和部分缓解者如果适合手术可行切除术,术后行放疗
Over the years there has been controversy over the timing and sequence of combined radiotherapy for small cell lung cancer. From February 1988 to September 1989, the Eastern United States Oncology Group and the M.D Anderson Cancer Center compared the above. All patients were confirmed by pathology or cytology. The lesions were confined to one side of the chest cavity. There was no pleural effusion and pericardial effusion, and the K score was above 70 points. The chemo-radiotherapy regimen in the sequential radiochemotherapy group was: cyclophosphamide 750 mg/m~2, the first day; vincristine 2 mg, the 8th day; cisplatin 20 mg/m~2; the first 1 to 3 days; 100mg/m~2, 1~3 days; 3 weeks for one course of treatment, total 3 courses. Complete and partial remission after chemotherapy if feasible for surgical resection, postoperative radiotherapy