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目的探讨乳腺颗粒细胞瘤的临床病理特征。方法对1例乳腺颗粒细胞瘤病例进行临床病理、免疫组化观察并文献复习。结果组织学特点:瘤细胞体积大,圆形或多边形,胞浆丰富充满嗜酸性颗粒,细胞核小,免疫组化染色显示:S-100、NSE均阳性,不表达CKpan、ER、PR。结论乳腺颗粒细胞瘤是一种罕见的良性肿瘤,在冰冻切片时易与乳腺癌混淆,其诊断主要依靠组织病理学和免疫组化标记。
Objective To investigate the clinicopathological features of granulosa cell tumor of breast. Methods One case of granulosa cell carcinoma of the breast was examined by clinicopathological and immunohistochemical methods and reviewed. Results Histological features: The tumor cells were bulky, round or polygonal. The cytoplasm was rich in eosinophilic granules with small nuclei. Immunohistochemical staining showed that both S-100 and NSE were positive and CKpan, ER and PR were not expressed. Conclusion Breast granulosa cell tumor is a rare benign tumor that is easily confused with breast cancer in frozen section. The diagnosis mainly depends on histopathology and immunohistochemistry.