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目的对缬沙坦,依那普利逆转高血压患者左室肥厚的疗效进行对照分析。方法选取高血压伴左室肥厚的患者70例。随机分成缬沙坦治疗组40例,依那普利治疗组30例,治疗6个月,辅以彩色多普勒超声心动图分别测定左室舒张末期内径(LVEDD),室间隔舒张末期厚度(LVST)左室后壁舒张末期厚度(LVPWT),计算左室重量指数。结果与治疗前比,2组治疗后,室间隔舒张末期厚度(LVST)左室后壁舒张末期厚度(LVPWT),左室重量指数(LVMI)均有下降(P<0.01),但2组无差异(P>0.05)。结论血管紧张素Ⅱ受体拮抗剂缬沙坦与血管紧张素转换酶抑制剂依那普利可逆转高血压患者的左室肥厚。
Objective To compare the efficacy of valsartan and enalapril in reversing the effect of left ventricular hypertrophy in hypertensive patients. Methods 70 patients with hypertension and left ventricular hypertrophy were selected. Randomly divided into valsartan 40 cases, enalapril 30 cases, for 6 months, supplemented by color Doppler echocardiography were measured left ventricular end-diastolic diameter (LVEDD), interventricular septum end-diastolic thickness ( Left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVST) were calculated. Results Compared with those before treatment, left ventricular end-diastolic wall thickness (LVPWT) and left ventricular mass index (LVMI) decreased after 2-treatment in both groups (P <0.01) Difference (P> 0.05). Conclusion Angiotensin Ⅱ receptor antagonist valsartan and angiotensin converting enzyme inhibitor enalapril can reverse left ventricular hypertrophy in hypertensive patients.