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乙型肝炎病毒(HBV)引起持续感染的机理迄今尚未弄清。干扰素(IFN)治疗慢性HBV携带者的效果不一,其中好转病例常见有一个急性肝炎过程,这可能反映了细胞毒性T细胞(Tc)对含有复制病毒细胞的溶解作用。Tc攻击靶细胞是通过对细胞表面与HLA Ⅰ类蛋白有关病毒抗原的识别。作者曾发现,IFN的处理能导致病毒感染的肝细胞上HLA Ⅰ类蛋白的表达增加。已证明Tc识别的主要病毒蛋白是HBeAg与HBcAg。本文研究了IFN对HBV感染肝细胞中HBsAg和HBcAg的表达,以弄清IFN的治疗作用是否与病毒抗原的表达有关。作者对23例慢性HBV携带者进行了研
The mechanism of hepatitis B virus (HBV) causing persistent infection has not yet been clarified. Interferon (IFN) is not effective in the treatment of chronic HBV carriers, with an acute hepatitis process commonly seen in patients with improvement, which may reflect the lysis of cytotoxic T cells (Tc) in cells that contain replicating virus. Tc targets target cells by recognizing the viral antigens associated with HLA class I proteins on the cell surface. The authors have found that IFN treatment leads to increased expression of HLA class I proteins on virus-infected hepatocytes. The major viral proteins identified by Tc have been identified as HBeAg and HBcAg. In this paper, we investigated the expression of HBsAg and HBcAg in hepatocytes infected with IFN in order to find out whether the therapeutic effect of IFN is related to the expression of viral antigens. The authors conducted a study of 23 chronic HBV carriers