目的:观察地诺前列酮栓用于足月妊娠促宫颈成熟及引产的临床效果及安全性。方法:选择有引产指征、宫颈Bishop评分<6分的足月妊娠初产妇62例作为观察组,并在阴道后穹隆置入地诺前列酮栓;抽取60例同等条件无催产素引产禁忌证并自愿接受催产素引产者为对照组,观察比较两组的促宫颈成熟总有效率、引产成功率、新生儿窒息率。结果:观察组用于足月妊娠促宫颈成熟的总有效率为93.5%,引产成功率为83.9%,显著高于对照组的65.0%和56.7%(P<0.05),且剖宫产率低于对照组(P<0.05),但新生儿出生体重及新生儿窒息率与对照组比较差异无统计学意义(P>0.05)。结论:地诺前列酮栓能有效促进足月妊娠宫颈成熟,引产成功率高,是一种方便、安全的促宫颈成熟及引产方法。 Objective: To observe the clinical effect and safety of dinoprostone suppository for cervical ripening and induction of labor during term pregnancy. Methods: 62 cases of primiparae of full-term pregnancy with cervical Bishop score <6 were selected as the observation group and dinoprostone suppositories were placed in the vaginal posterior fornix. Sixty cases with the same conditions without oxytocin were induced contraindications And voluntary acceptance of oxytocin induced labor as a control group, observed and compared the total efficiency of cervical ripening, induction of labor success rate, neonatal asphyxia. Results: The total effective rate of pregnancy induced cervix maturation in observation group was 93.5%, the successful rate of induced labor was 83.9%, significantly higher than 65.0% and 56.7% in control group (P <0.05), and the rate of cesarean section was low (P <0.05). However, there was no significant difference in birth weight and neonatal asphyxia between the two groups (P> 0.05). Conclusion: The dinoprostone suppository can effectively promote the maturation of the cervix in full-term pregnancy and has a high success rate of induction. It is a convenient and safe method to promote cervical ripening and induction of labor.