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目的探讨高血压患者脑钠钛(BNP)变化水平和左室肥厚(LVH)的临床指标的相关性。方法选取原发性高血压患者无左室肥厚患者32例(NLVH组),高血压合并左室肥厚患者31例(LVH组)及血压正常的健康体检者(对照组)31例,采用酶联免疫吸附法(ELISA)测定其BNP浓度,采用超声心动图检测左室重量指数(LVMI),观察BNP水平和左室重量指数的关系。结果LVH组BNP水平显著高于NLVH组及对照组,差异有统计学意义(P<0.01)。NLVH组高于对照组(P<0.01),BNP和左室重量指数呈正相关性(P<0.01)。结论BNP水平变化可以作为高血压及左室肥厚的监测的重要指标。
Objective To investigate the correlation between the changes of brain natriuretic peptide (BNP) and clinical indexes of left ventricular hypertrophy (LVH) in hypertensive patients. Methods Thirty-two patients with essential hypertension without left ventricular hypertrophy (NLVH group), 31 patients with hypertension (LVH group) and normal blood pressure healthy volunteers (control group) The concentration of BNP was measured by ELISA. Left ventricular mass index (LVMI) was measured by echocardiography. The relationship between BNP level and left ventricular mass index was observed. Results The level of BNP in LVH group was significantly higher than that in NLVH group and control group (P <0.01). NLVH group was higher than that of control group (P <0.01), BNP and left ventricular mass index were positively correlated (P <0.01). Conclusion BNP level changes can be used as an important indicator of monitoring of hypertension and left ventricular hypertrophy.