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加拿大有人认为,夜间一次服甲氰咪胍800mg对减少夜间胃酸分泌比日服二次更为有效。对4名健康志愿者和4名经内窥镜证明已愈合的十二指肠溃疡病人,按两种剂量授予甲氰咪胍,发现在减少二十四小时胃内平均酸度方面,同样有效。但服800mg组的十二指肠溃疡病人,夜间胃液酸度减少95％,而正常志愿者则减少89％。不仅如此,服800mg组的胃液PH整夜直到黎明都保持在4以上,而400mg日服二次者,则PH>4仅保持五个小时。
Some people in Canada believe that nighttime cimetidine 800mg on the night to reduce gastric acid secretion than the second service is more effective. Cimetidine was administered in two doses to four healthy volunteers and four endoscopically proven duodenal ulcers patients and was found to be equally effective in reducing the average intragastric acidity within twenty-four hours. However, taking 800mg duodenal ulcer patients, gastric acidity decreased 95% night, while the normal volunteers decreased 89%. Not only that, the group served 800mg gastric juice PH until dawn are maintained at 4 above 400mg on the second, PH> 4 only for five hours.