近年来,大量动物实验和人类肾小球疾病临床病理研究发现,肾小球疾病的发展和预后不仅与肾小球本身的损害有关(肾小球上皮、内皮细胞损伤、系膜细胞增殖、细胞外基质堆积、肾小球硬化等),更与其肾小管-间质病变的严重程度密切相关。对膜性肾病的多因素相关分析结果表明,肾小管-间质损伤是决定10年肾脏存活率的最重要影响因素,其影响程度远较肾小球病变严重程度更为重要[1-2]。在 In recent years, a large number of animal experiments and human glomerular disease clinicopathological studies found that the development and prognosis of glomerular disease not only with glomerular damage itself (glomerular epithelium, endothelial cell injury, mesangial cell proliferation, cells External matrix accumulation, glomerular sclerosis, etc.), but also with its severity of tubulointerstitial lesions are closely related. Multivariate correlation analysis of membranous nephropathy showed that tubulointerstitial injury is the most important factor that determines the 10-year renal survival rate, and the extent of its influence is much more important than the severity of glomerular disease [1-2] . in