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目的 探讨血清透明质酸(HA)、层粘蛋白(LN)、Ⅲ型前胶原(PC Ⅲ)在各型慢性乙型肝炎抗纤维化治疗中的价值。方法 应用复方丹参注射液20ml加入10％葡萄糖液体250ml中静脉滴注,每日1次。复方鳖甲软肝片4片,每日3次,口服。3个月为1疗程。结果 124例慢性乙型肝炎患者经过3个月的抗纤维化治疗。在慢性肝炎轻、中度时,血清HA、LN、PC Ⅲ均有显著下降(P<0.05)。慢性肝炎重度及肝硬化时,血清HA、LN、PC Ⅲ下降无差异性(P>0.05)。结论联合检测血清肝纤维化指标在各型慢性乙型肝炎抗纤维化治疗中具有一定的参考价值,可在基层医疗单位推广应用。
Objective To investigate the value of serum hyaluronic acid (HA), laminin (LN) and type Ⅲ procollagen (PC Ⅲ) in the treatment of various types of chronic hepatitis B patients with anti-fibrosis. Methods The compound Danshen injection 20ml added 10% glucose solution 250ml intravenous infusion, once daily. Fufang Biejia Ruangan tablets 4, 3 times daily, orally. 3 months for a course of treatment. Results 124 patients with chronic hepatitis B after 3 months of anti-fibrosis treatment. In mild and moderate chronic hepatitis, the serum HA, LN, PC Ⅲ were significantly decreased (P <0.05). Serum levels of HA, LN and PC Ⅲ were not significantly different between chronic hepatitis and severe cirrhosis (P> 0.05). Conclusion The combined detection of serum liver fibrosis indicators in various types of chronic hepatitis B anti-fibrosis treatment has a certain reference value, can be popularized in the primary medical units.